Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976021 | 0.88 | PDE10A (0.56) | PDE10ACFTRTDP1 | |
| SCHEMBL30118753 | 0.88 | SMN1; SMN2 (0.37) | PDE10AALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23976168 | 0.88 | SMN1; SMN2 (0.37) | PDE10AALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23976579 | 0.87 | KDR (0.41) | ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL30118807 | 0.87 | KDR (0.41) | ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL30118769 | 0.86 | ALDH1A1 (0.39) | PDE10AALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23975936 | 0.86 | ALDH1A1 (0.39) | PDE10AALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL30118785 | 0.84 | PDE10A (0.45) | PDE10ACFTRTDP1 | |
| SCHEMBL23975833 | 0.84 | PDE10A (0.45) | PDE10ACFTRTDP1 | |
| SCHEMBL23975721 | 0.84 | PDE10A (0.48) | PDE10AALDH1A1SMN1; SMN2L3MBTL1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |