SCHEMBL23978762

SCHEMBL23978762

NC(=O)NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCNC2)C(=O)OCc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ITGB2 P05107 15/20 0.42
ICAM1 P05362 15/20 0.42
ITGAL P20701 15/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24803392 0.85 EPHX2 (0.42) ITGB2ICAM1ITGAL
SCHEMBL23978775 0.85 EPHX2 (0.42) ITGB2ICAM1ITGAL
SCHEMBL30083857 0.85 EPHX2 (0.42) ITGB2ICAM1ITGAL
SCHEMBL13588336 0.83 POLB (0.48) ITGB2ICAM1ITGAL
SCHEMBL13588337 0.81 ITGB2 (0.55) ITGB2ICAM1ITGAL
SCHEMBL20833731 0.81 ITGB2 (0.55) ITGB2ICAM1ITGAL
Hydrochloric Acid SCHEMBL31021044 0.80 ITGB2 (0.55) ITGB2ICAM1ITGAL
Hydrochloric Acid SCHEMBL28387762 0.80 ITGB2 (0.55) ITGB2ICAM1ITGAL
SCHEMBL23979070 0.79 ITGB2 (0.51) ITGB2ICAM1ITGAL
SCHEMBL23978724 0.78 ITGB2 (0.41) ITGB2ICAM1ITGAL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021222789-A1 INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-11-04 WO disclosed