Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.38 |
| ▸ | ITGAL | P20701 | 6/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.35 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083857 | 1.00 | EPHX2 (0.42) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL24803392 | 1.00 | EPHX2 (0.42) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL30279451 | 0.90 | ITGB2 (0.46) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL30083821 | 0.90 | ITGB2 (0.46) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL29019146 | 0.90 | ITGB2 (0.46) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL23978711 | 0.90 | ITGB2 (0.46) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL23978931 | 0.90 | ITGB2 (0.46) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL24803416 | 0.89 | EPHX2 (0.40) | EPHX2ITGB2ICAM1ITGALTAS1R3 | |
| SCHEMBL26502502 | 0.86 | ITGB2 (0.44) | EPHX2ITGB2ICAM1ITGAL | |
| SCHEMBL26106382 | 0.86 | ITGB2 (0.51) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |