Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 3/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979030 | 0.90 | NPC1 (0.46) | FOLH1ITGALITGB2ICAM1ITGB1 | |
| SCHEMBL23979033 | 0.88 | MEN1 (0.57) | ITGB1ITGA4 | |
| SCHEMBL23978899 | 0.86 | ITGB1 (0.43) | ITGALITGB1ITGA5ITGA4ROCK2 | |
| SCHEMBL3876678 | 0.86 | ITGAL (0.48) | FOLH1ITGALITGB2ICAM1ITGB1 | |
| SCHEMBL3869362 | 0.83 | ITGAL (0.49) | FOLH1ITGALITGB2ICAM1ITGB1 | |
| SCHEMBL3871439 | 0.80 | ITGAL (0.51) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL16286432 | 0.80 | ITGAL (0.51) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL30227636 | 0.80 | ITGAL (0.51) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL3866729 | 0.80 | ITGAL (0.51) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL23979041 | 0.80 | EPHX2 (0.44) | FOLH1ITGALITGB2ICAM1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |