Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 18/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 18/20 | 0.58 |
| ▸ | ITGAL | P20701 | 18/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129657 | 0.82 | ITGB2 (0.62) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL27044184 | 0.80 | ITGB2 (0.67) | ITGB2ICAM1ITGAL | |
| SCHEMBL18885628 | 0.79 | ITGB2 (0.59) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL21003874 | 0.78 | HDAC6 (0.64) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL18868005 | 0.76 | ITGB2 (0.42) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL13894069 | 0.75 | ITGB2 (0.67) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL13658127 | 0.74 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL18362337 | 0.74 | HDAC6 (0.46) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL13894281 | 0.74 | ITGB2 (0.56) | ITGB2ICAM1ITGALHDAC6 | |
| SCHEMBL20439976 | 0.74 | POLB (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |