Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979459 | 0.88 | ABL1 (0.48) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL6921464 | 0.87 | IDO1 (0.50) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL16790458 | 0.86 | EPHX2 (0.48) | ACLYMAPTKDM4AKCNA5MYC | |
| SCHEMBL27988801 | 0.85 | IDO1 (0.53) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL4296419 | 0.84 | IDO1 (0.46) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL28215080 | 0.84 | KDM4A (0.42) | KDM4AKCNA5 | |
| SCHEMBL23997640 | 0.83 | IDO1 (0.52) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL3734185 | 0.83 | ANO1 (0.51) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL21987969 | 0.82 | IDO1 (0.48) | IDO1GAAALDH1A1KDM4EHPGD | |
| SCHEMBL4757294 | 0.82 | GAA (0.49) | IDO1GAAALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667236-B | 1, 5-Dihydro-2, 4-benzodiazepine-3-one derivative and application thereof | 江苏恩华药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| US-20230132621-A1 | 1,5-DIHYDRO-2,4-BENZODIAZEPINE-3-ONE DERIVATIVE AND APPLICATION THEREOF | JIANGSU NHWA PHARMACEUTICAL CO., LTD (CN) | 2023-05-04 | — | — | US | disclosed |
| CN-115667236-A | 1,5-dihydro-2,4-benzodiazepine-3-one derivative and use thereof | 江苏恩华药业股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| WO-2021218863-A1 | 1,5-DIHYDRO-2,4-BENZODIAZEPINE-3-ONE DERIVATIVE AND APPLICATION THEREOF | 江苏恩华药业股份有限公司 (CN) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132621-A1 | 1,5-DIHYDRO-2,4-BENZODIAZEPINE-3-ONE DERIVATIVE AND APPLICATION THEREOF | HTR2C, HTR2A, HTR2B | IDO1 1690/4885GAA 1765/4885ACLY 3934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.