Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239804 | 1.00 | CHEK2 (0.59) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL254007 | 0.89 | CHEK2 (0.59) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL254005 | 0.89 | CHEK2 (0.59) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL4011646 | 0.87 | CHEK2 (0.68) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL238373 | 0.87 | CHEK2 (0.58) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL238371 | 0.87 | CHEK2 (0.58) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL1624226 | 0.85 | CHEK2 (0.51) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL1084251 | 0.85 | CHEK2 (0.67) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL1084555 | 0.84 | CHEK2 (0.80) | CHEK2MEN1KMT2ASMAD3MAPT | |
| SCHEMBL1084832 | 0.84 | CHEK2 (0.80) | CHEK2MEN1KMT2ASMAD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957482-B1 | QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-01-04 | — | — | EP | disclosed |