Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254007 | 1.00 | CHEK2 (0.59) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL239802 | 0.89 | CHEK2 (0.59) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL239804 | 0.89 | CHEK2 (0.59) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL1623601 | 0.88 | CHEK2 (0.61) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL4011646 | 0.88 | CHEK2 (0.68) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL1624429 | 0.86 | CHEK2 (0.51) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL14535483 | 0.85 | CHEK2 (0.58) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL1084251 | 0.85 | CHEK2 (0.67) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL1084555 | 0.85 | CHEK2 (0.80) | CHEK2MEN1KMT2ASMAD3ALDH1A1 | |
| SCHEMBL1084832 | 0.85 | CHEK2 (0.80) | CHEK2MEN1KMT2ASMAD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957482-B1 | QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-01-04 | — | — | EP | disclosed |