Sugi Predict

Sugi Predict / Compounds / SCHEMBL2398534

SCHEMBL2398534

SCHEMBL2398534

[CH2]C(/C=C/C)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ ATM Q13315 1/20 0.38
▸ DPP4 P27487 2/20 0.36
▸ F2 P00734 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ MIF P14174 2/20 0.35
▸ TAAR1 Q96RJ0 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ HTR2A P28223 1/20 0.34
▸ HRH1 P35367 1/20 0.34
▸ ADRA2A P08913 1/20 0.33
▸ ADRA2C P18825 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ HIF1A Q16665 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2398537 1.00 MEN1 (0.38) MEN1KMT2AATMDPP4F2
SCHEMBL31028945 0.84 MEN1 (0.41) MEN1KMT2AATMDPP4F2
SCHEMBL28238064 0.81 TAAR1 (0.33) MIFTAAR1LMNAHTR2AHRH1
SCHEMBL6568105 0.78 TSHR (0.46) MEN1KMT2AATMDPP4F2
SCHEMBL8613849 0.77 MEN1 (0.39) MEN1KMT2AATMDPP4F2
SCHEMBL692130 0.77 MEN1 (0.39) MEN1KMT2AATMDPP4F2
SCHEMBL3021502 0.77 DPP4 (0.38) DPP4F2TSHRMIFTAAR1
Methane SCHEMBL11662057 0.75 MEN1 (0.38) MEN1KMT2AATMDPP4F2
SCHEMBL5855141 0.75 TRPA1 (0.45) MEN1KMT2AATMDPP4F2
SCHEMBL5855165 0.75 TRPA1 (0.45) MEN1KMT2AATMDPP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8497382-B2 Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-07-30 — — US disclosed
CN-102300853-A Carboxylic acid derivatives containing thiazole ring and pharmaceutical use thereof — 2011-12-28 — — CN disclosed
EP-2380884-A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2011-10-26 — — EP disclosed
US-20110237630-A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-09-29 — — US disclosed
US-8026370-B2 Peroxisome proliferator antagonist; hyperlipemia agents; arteriosclerosis; antiischemic agents MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-09-27 — — US disclosed
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof MITSUBISHI PHAMA CORPORATION (JP) 2008-07-10 — — US disclosed
CN-101068797-A Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof MITSUBISHI PHARMA CORP (JP) 2007-11-07 — — CN disclosed
EP-1816128-A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF Mitsubishi Pharma Corporation (JP) 2007-08-08 — — EP disclosed
EP-1505156-B1 Process for the enantioselective preparation of secondary alcohols by lipase catalysed solvolysis of the corresponding acetoacetic acid ester CONSORTIUM ELEKTROCHEM IND (DE) 2005-12-07 — — EP disclosed
EP-1572189-A1 METHOD OF LOWERING CRP AND REDUCING SYSTEMIC INFLAMMATION Warner-Lambert Company LLC (US) 2005-09-14 — — EP disclosed
CN-1268123-A Benzimidazole derivatives FUJISAWA PHARMACEUTICAL CO (JP) 2000-09-27 — — CN disclosed
EP-1020452-A1 BENZIMIDAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-19 — — EP disclosed
EP-0820428-B1 TERMINAL CARBOXY OR TETRAZOLE GROUPS CONTAINING DIALKYL ETHERS WARNER LAMBERT CO (US) 2000-05-10 — — EP disclosed
US-5783600-A FOR ELEVATING HDL CHOLESTEROL; ANTIDIABETIC AGENTS WARNER-LAMBERT COMPANY (US) 1998-07-21 — — US disclosed
US-5756544-A ADMINISTERING TO LOWER LEVELS OF LOW DENSITY LIPOPROTEINS AND TO RAISE THE LEVELS OF HIGH DENSITY LIPOPROTEINS WARNER-LAMBERT COMPANY (US) 1998-05-26 — — US disclosed
CN-1182415-A Dialkyl ethers containing terminal carboxylic acid groups or tetrazolyl groups WARNER LAMBERT CO (US) 1998-05-20 — — CN disclosed
US-5750569-A LOWERING PLASMA LIPIDS WARNER-LAMBERT COMPANY (US) 1998-05-12 — — US disclosed
EP-0820428-A1 TERMINAL CARBOXY OR TETRAZOLE GROUPS CONTAINING DIALKYL ETHERS WARNER-LAMBERT COMPANY (US) 1998-01-28 — — EP disclosed
US-5648387-A Carboxyalkylethers, formulations, and treatment of vascular diseases WARNER-LAMBERT COMPANY (US) 1997-07-15 — — US disclosed
WO-1996030328-A1 TERMINAL CARBOXY OR TETRAZOLE GROUPS CONTAINING DIALKYL ETHERS WARNER-LAMBERT COMPANY (US) 1996-10-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof PPARA, PPARD, PPARG MEN1 4667/4885KMT2A 2672/4885ATM 2194/4885
US-20110237630-A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF PPARA, PPARD, PPARG MEN1 4414/4885KMT2A 571/4885ATM 1882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.