Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975730 | 0.72 | POLB (0.40) | POLBKDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL30225189 | 0.72 | POLB (0.40) | POLBKDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL23975763 | 0.72 | POLB (0.38) | POLBKDM4EALDH1A1KMT2ADRD2 | |
| SCHEMBL23976200 | 0.71 | DRD2 (0.32) | POLBDRD2DRD4DRD3 | |
| SCHEMBL23991439 | 0.71 | KDM4E (0.44) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL30225288 | 0.67 | POLB (0.31) | POLB | |
| SCHEMBL23976187 | 0.67 | POLB (0.31) | POLB | |
| SCHEMBL30225350 | 0.65 | GAA (0.38) | POLBKDM4EKMT2A | |
| SCHEMBL23976386 | 0.64 | GAA (0.39) | POLBKDM4EALDH1A1CCR6ATM | |
| SCHEMBL30225202 | 0.64 | GAA (0.39) | POLBKDM4EALDH1A1CCR6ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |