Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976572 | 0.85 | PDE10A (0.44) | PDE10AKDM4ENPC1RAB9ACFTR | |
| SCHEMBL23986871 | 0.83 | PDE10A (0.41) | PDE10ANPC1RAB9ACFTRMEN1 | |
| SCHEMBL25926506 | 0.83 | PDE10A (0.42) | PDE10ANPC1RAB9ACFTRMEN1 | |
| SCHEMBL23975783 | 0.82 | PDE10A (0.40) | PDE10ANPC1RAB9ACFTRMEN1 | |
| SCHEMBL30118760 | 0.82 | PDE10A (0.49) | PDE10ABCHEACHEKDM4ENPC1 | |
| SCHEMBL23976150 | 0.82 | PDE10A (0.49) | PDE10ABCHEACHEKDM4ENPC1 | |
| SCHEMBL30118661 | 0.81 | PDE10A (0.50) | PDE10AALOX15MEN1ALDH1A1KMT2A | |
| SCHEMBL23975642 | 0.81 | PDE10A (0.50) | PDE10AALOX15MEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL30225329 | 0.81 | PDE10A (0.48) | PDE10ABCHEACHEKDM4ENPC1 | |
| SCHEMBL23986773 | 0.79 | PDE10A (0.40) | PDE10AKDM4ECFTRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |