Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 6/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25926506 | 0.90 | PDE10A (0.42) | PDE10AMETAP2METAP1CFTRTDP1 | |
| SCHEMBL23976572 | 0.84 | PDE10A (0.44) | PDE10AMETAP2METAP1CFTRTDP1 | |
| SCHEMBL23986910 | 0.82 | PDE10A (0.46) | PDE10ACFTRMEN1KMT2ANPC1 | |
| SCHEMBL23975776 | 0.81 | PDE10A (0.44) | PDE10AMETAP2METAP1CFTRTDP1 | |
| SCHEMBL30118645 | 0.81 | PDE10A (0.44) | PDE10AMETAP2METAP1CFTRTDP1 | |
| SCHEMBL24702095 | 0.81 | LMNA (0.38) | PDE10ACFTRTDP1MEN1KMT2A | |
| SCHEMBL23975712 | 0.81 | PDE10A (0.36) | PDE10ACFTRTDP1MEN1KMT2A | |
| SCHEMBL23986871 | 0.81 | PDE10A (0.41) | PDE10AMETAP2METAP1CFTRTDP1 | |
| SCHEMBL23975719 | 0.80 | PDE10A (0.44) | PDE10AMETAP2METAP1CFTRTDP1 | |
| SCHEMBL23986773 | 0.79 | PDE10A (0.40) | PDE10AMETAP2METAP1CFTRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |