Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22303469 | 1.00 | HTR2C (0.46) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| SCHEMBL25707304 | 0.89 | HTR2C (0.45) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| SCHEMBL23508701 | 0.89 | HTR2C (0.45) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| Hydrochloric Acid SCHEMBL25347445 | 0.88 | HTR2C (0.44) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| Hydrochloric Acid SCHEMBL30486634 | 0.88 | HTR2C (0.44) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| Hydrochloric Acid SCHEMBL30486474 | 0.88 | HTR2C (0.44) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| SCHEMBL24879518 | 0.83 | HTR2C (0.56) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| SCHEMBL21940604 | 0.83 | MAPK3 (0.45) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| SCHEMBL27454640 | 0.83 | MAPK3 (0.45) | HTR2CHTR2BHTR2ASIGMAR1ADRB2 | |
| SCHEMBL29603948 | 0.81 | MAPK3 (0.37) | HTR2CHTR2BHTR2AADRA2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282782-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | GENZYME CORP (US) | 2025-09-11 | — | — | US | disclosed |
| WO-2023282702-A1 | SHP2 INHIBITOR AND USE THEREOF | 주식회사 카나프테라퓨틱스 | 2023-01-12 | — | — | WO | disclosed |
| WO-2021218755-A1 | SHP2 INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 (CN) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250282782-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | PTPN5, PTPN2, PTPRJ | HTR2C 3250/4885HTR2B 4394/4885HTR2A 3451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.