Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 16/20 | 0.60 |
| ▸ | BMP4 | P12644 | 4/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988996 | 0.91 | ACVR1 (0.60) | ACVR1BMP4PTGDR2BMPR1BACVR1B | |
| SCHEMBL23988873 | 0.86 | ACVR1 (0.62) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988735 | 0.84 | ACVR1 (0.62) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988747 | 0.83 | ACVR1 (0.50) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988856 | 0.82 | BMP4 (0.55) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988907 | 0.82 | ACVR1 (0.49) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988880 | 0.81 | ACVR1 (0.58) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988752 | 0.81 | ACVR1 (0.50) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988847 | 0.81 | ACVR1 (0.60) | ACVR1BMP4BMPR1BACVR1BACVRL1 | |
| SCHEMBL23988886 | 0.80 | ACVR1 (0.60) | ACVR1BMP4BMPR1BACVR1BACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |