Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 9/20 | 0.68 |
| ▸ | KDR | P35968 | 9/20 | 0.68 |
| ▸ | FLT4 | P35916 | 5/20 | 0.68 |
| ▸ | PRKAB2 | O43741 | 9/20 | 0.66 |
| ▸ | PRKAG1 | P54619 | 9/20 | 0.66 |
| ▸ | PRKAA2 | P54646 | 9/20 | 0.66 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.66 |
| ▸ | PRKAG3 | Q9UGI9 | 9/20 | 0.66 |
| ▸ | PRKAG2 | Q9UGJ0 | 9/20 | 0.66 |
| ▸ | PRKAB1 | Q9Y478 | 9/20 | 0.66 |
| ▸ | BMP4 | P12644 | 7/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.66 |
| ▸ | LCK | P06239 | 5/20 | 0.66 |
| ▸ | SRC | P12931 | 5/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.66 |
| ▸ | RPS6KA1 | Q15418 | 5/20 | 0.66 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.66 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.66 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.66 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988897 | 0.87 | KDR (0.51) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL24409713 | 0.86 | FLT1 (0.69) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL13126027 | 0.86 | KDR (0.72) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL23989029 | 0.85 | FLT1 (0.71) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL26867386 | 0.85 | FLT1 (0.68) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL13126013 | 0.85 | KDR (0.71) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL24409700 | 0.85 | FLT1 (0.67) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL26939422 | 0.85 | FLT1 (0.70) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL11953875 | 0.85 | KDR (0.83) | FLT1KDRFLT4PRKAB2PRKAG1 | |
| SCHEMBL23988879 | 0.84 | ACVR1 (0.54) | FLT1KDRFLT4PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |