Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 8/20 | 0.54 |
| ▸ | KDR | P35968 | 9/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.49 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.47 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.47 |
| ▸ | BMP4 | P12644 | 2/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988897 | 0.90 | KDR (0.51) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL23989005 | 0.88 | ACVR1 (0.51) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL23988714 | 0.84 | FLT1 (0.68) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL23988925 | 0.84 | ACVR1 (0.46) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL24409783 | 0.84 | ACVR1 (0.55) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL17441819 | 0.83 | ACVR1 (0.52) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL17441887 | 0.83 | ACVR1 (0.59) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL23988901 | 0.83 | KDR (0.48) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL17442070 | 0.82 | ACVR1 (0.60) | ACVR1KDRFLT1FLT4ACVRL1 | |
| SCHEMBL17442061 | 0.82 | ACVR1 (0.53) | ACVR1KDRFLT1FLT4ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |