Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.59 |
| ▸ | ACVR1 | Q04771 | 12/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 9/20 | 0.56 |
| ▸ | ACVRL1 | P37023 | 9/20 | 0.56 |
| ▸ | BMPR1A | P36894 | 9/20 | 0.56 |
| ▸ | ACVR1B | P36896 | 8/20 | 0.56 |
| ▸ | BMP4 | P12644 | 4/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.49 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988800 | 0.93 | KDR (0.59) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23989002 | 0.88 | ACVR1 (0.72) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988798 | 0.84 | KDR (0.60) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988696 | 0.83 | KDR (0.55) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988885 | 0.82 | ACVR1 (0.56) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988807 | 0.82 | KDR (0.54) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988805 | 0.82 | KDR (0.54) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL12779951 | 0.81 | ACVRL1 (0.78) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988758 | 0.81 | ACVR1 (0.57) | KDRACVR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL17442355 | 0.81 | ACVR1 (0.74) | KDRACVR1BMPR1BACVRL1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |