Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 13/20 | 0.58 |
| ▸ | BMP4 | P12644 | 5/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 10/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 9/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 9/20 | 0.45 |
| ▸ | ACVR1B | P36896 | 9/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.45 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988972 | 0.85 | ACVR1 (0.46) | ACVR1BMP4ACVRL1BMPR1BBMPR1A | |
| SCHEMBL23988880 | 0.78 | ACVR1 (0.58) | ACVR1BMP4ACVRL1BMPR1BBMPR1A | |
| SCHEMBL23988873 | 0.75 | ACVR1 (0.62) | ACVR1BMP4ACVRL1BMPR1BBMPR1A | |
| SCHEMBL22077951 | 0.75 | ACVR1 (1.00) | ACVR1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL23988890 | 0.74 | ACVR1 (0.61) | ACVR1 | |
| SCHEMBL23989002 | 0.74 | ACVR1 (0.72) | ACVR1BMP4ACVRL1BMPR1BBMPR1A | |
| SCHEMBL23988751 | 0.73 | ACVR1 (0.62) | ACVR1ACVRL1BMPR1BBMPR1AACVR1B | |
| SCHEMBL23988838 | 0.73 | ACVR1 (0.62) | ACVR1BMP4ACVRL1BMPR1BBMPR1A | |
| SCHEMBL23988856 | 0.72 | BMP4 (0.55) | ACVR1BMP4ACVRL1BMPR1BBMPR1A | |
| SCHEMBL23988791 | 0.72 | BMP4 (0.67) | ACVR1BMP4ACVRL1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |