Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 1/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | HPD | P32754 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409 | 0.85 | MAOB (0.61) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL22316 | 0.84 | MAOB (0.66) | MAOBMAOANR4A2SMPD1MEN1 | |
| SCHEMBL22564 | 0.82 | MAOB (0.64) | MAOBSMPD1TLR4TLR2SPHK2 | |
| SCHEMBL791305 | 0.81 | MAOB (0.73) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL4697290 | 0.79 | APP (0.70) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL31533129 | 0.79 | APP (0.70) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL4638746 | 0.78 | MAOB (0.72) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL13483792 | 0.78 | MAOB (0.61) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL13462917 | 0.77 | MAOB (0.60) | MAOBMAOANR4A2RXRARXRB | |
| SCHEMBL23720 | 0.77 | MAOB (0.60) | MAOBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |