Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25004500 | 0.85 | PDE10A (0.38) | PDE10AMAP3K5EGFR | |
| SCHEMBL23995228 | 0.82 | PDE10A (0.44) | PDE10AMAP3K5EGFR | |
| SCHEMBL23994572 | 0.80 | NT5E (0.34) | HTR2AHTR2C | |
| SCHEMBL23993628 | 0.80 | NT5E (0.34) | HTR2AHTR2C | |
| SCHEMBL23994614 | 0.78 | HTR3A (0.34) | — | |
| SCHEMBL23995229 | 0.77 | PDE10A (0.32) | PDE10A | |
| SCHEMBL25005811 | 0.73 | — | — | |
| SCHEMBL25004503 | 0.73 | HTR3A (0.32) | — | |
| SCHEMBL23993484 | 0.70 | MAP3K5 (0.36) | MAP3K5 | |
| SCHEMBL23994584 | 0.70 | HTR3A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | ENTPD5, ENTPD1, NT5E | PDE10A 484/4885MAP3K5 3994/4885OPRK1 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.