Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23995540 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL25005274 | 0.81 | HTR2C (0.34) | SMN1; SMN2NPC1RAB9ACHRNB2CHRNA4 | |
| SCHEMBL25004973 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL23993566 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL23995385 | 0.75 | SLC6A4 (0.43) | SMN1; SMN2ALDH1A1NPC1RAB9APKM | |
| SCHEMBL24444859 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL23994285 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL23992774 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL22860346 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL25005441 | 0.70 | SLC6A4 (0.49) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |