Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 3/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997262 | 0.73 | MAPT (0.43) | NR3C1ALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL14071507 | 0.72 | SLC7A5 (0.46) | GLSSLC7A5MTNR1AMTNR1B | |
| SCHEMBL23997165 | 0.71 | KMT2A (0.41) | ALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL960293 | 0.69 | SLC7A5 (0.46) | GLSSLC7A5MTNR1AMTNR1B | |
| SCHEMBL16355777 | 0.69 | SLC7A5 (0.44) | GLSSLC7A5MTNR1AMTNR1B | |
| SCHEMBL15432956 | 0.68 | SLC7A5 (0.48) | GLSSLC7A5MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL10211636 | 0.68 | PTGS1 (0.43) | GLSSLC7A5MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL27520004 | 0.67 | TSHR (0.53) | SLC7A5MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL1346095 | 0.67 | TSHR (0.56) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL23997403 | 0.67 | HDAC1 (0.39) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226003-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2021-11-11 | — | — | WO | disclosed |