Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.53 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 10/20 | 0.46 |
| ▸ | CCNC | P24863 | 9/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25841291 | 0.89 | GAK (0.48) | GAKRIPK2COQ8ANLKCDK8 | |
| SCHEMBL23999974 | 0.88 | GAK (0.48) | GAKRIPK2COQ8ANLKCDK8 | |
| SCHEMBL23999756 | 0.86 | GAK (0.62) | GAKRIPK2COQ8ANLKCDK8 | |
| SCHEMBL23999795 | 0.84 | RET (0.43) | RIPK2MAPKAPK2 | |
| SCHEMBL23999501 | 0.82 | HCAR3 (0.48) | MAPKAPK2 | |
| SCHEMBL23999539 | 0.82 | MAPK1 (0.47) | GAKRIPK2COQ8ANLKMAPKAPK2 | |
| SCHEMBL24010545 | 0.81 | GAK (0.59) | GAKRIPK2COQ8ANLKCDK8 | |
| SCHEMBL25826242 | 0.80 | MAPT (0.54) | CDK8CCNCMAP4K2DYRK3GSK3B | |
| SCHEMBL19151445 | 0.79 | MAPT (0.56) | GAKRIPK2COQ8ANLKCDK8 | |
| SCHEMBL30180417 | 0.79 | MAPT (0.56) | GAKRIPK2COQ8ANLKCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226519-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |