SCHEMBL2400328

SCHEMBL2400328

CC(C)C(F)[CH]c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.38
ALDH1A1 P00352 2/20 0.36
TSHR P16473 1/20 0.36
MAOB P27338 1/20 0.36
CYP2A6 P11509 1/20 0.36
NFE2L2 Q16236 1/20 0.36
TRPA1 O75762 1/20 0.35
AHR P35869 1/20 0.35
LMNA P02545 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CHAT P28329 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8203826 0.82 HTR2A (0.39) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL27633315 0.79 HTR2A (0.40) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL8704500 0.77 HTR2A (0.39) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL184701 0.76 ALDH1A1 (0.41) ALDH1A1TSHRMAOBCYP2A6NFE2L2
SCHEMBL315078 0.76 HTR2A (0.41) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL9341987 0.73 HTR2A (0.36) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL28103424 0.73 HTR2A (0.36) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL9772815 0.72 ALDH1A1 (0.43) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL3336700 0.72 HTR2A (0.39) HTR2AALDH1A1TSHRMAOBCYP2A6
SCHEMBL3486113 0.72 ALDH1A1 (0.43) HTR2AALDH1A1TSHRMAOBAHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8252559-B2 Methods and systems for selective fluorination of organic molecules THE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2012-08-28 US disclosed
US-8026085-B2 Methods and systems for selective fluorination of organic molecules CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2011-09-27 US disclosed
US-20090209010-A1 METHODS AND SYSTEMS FOR SELECTIVE FLUORINATION OF ORGANIC MOLECULES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2009-08-20 US disclosed
EP-2069513-A2 METHODS AND SYSTEMS FOR SELECTIVE FLUORINATION OF ORGANIC MOLECULES California Institute of Technology (US) 2009-06-17 EP disclosed
US-20090061471-A1 Methods and systems for selective fluorination of organic molecules INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2009-03-05 US disclosed
WO-2008016709-A9 METHODS AND SYSTEMS FOR SELECTIVE FLUORINATION OF ORGANIC MOLECULES CALIFORNIA INST OF TECHN (US) 2008-05-29 WO disclosed
WO-2008016709-A2 METHODS AND SYSTEMS FOR SELECTIVE FLUORINATION OF ORGANIC MOLECULES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2008-02-07 WO disclosed