Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.51 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.51 |
| ▸ | DNMT3L | Q9UJW3 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | BCR | P11274 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24006110 | 1.00 | POLB (0.55) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL30287677 | 1.00 | POLB (0.55) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL30232750 | 1.00 | POLB (0.55) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL26328429 | 0.92 | KCNK3 (0.57) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL26321817 | 0.89 | ABL1 (0.51) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL26315464 | 0.86 | KCNK3 (0.51) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL30290811 | 0.85 | KCNK3 (0.53) | POLBKCNK3KCNK9DNMT1DNMT3A | |
| SCHEMBL24010669 | 0.85 | KCNK3 (0.53) | POLBKCNK3KCNK9DNMT1DNMT3A | |
| SCHEMBL24006101 | 0.85 | POLB (0.61) | POLBMAPTKCNK3KCNK9DNMT1 | |
| SCHEMBL30232732 | 0.85 | KCNK3 (0.57) | POLBMAPTKCNK3KCNK9DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115996939-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| WO-2021226517-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | POLB 2552/4885MAPT 3962/4885KCNK3 2395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.