Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24003985 | 0.88 | JAK2 (0.44) | SMARCA2SMARCA4HDAC3HDAC1HDAC2 | |
| SCHEMBL24003988 | 0.86 | MAPK8 (0.46) | MAPK8MAPK10SMARCA2SMARCA4HDAC3 | |
| SCHEMBL26322770 | 0.78 | MAPK8 (0.48) | MAPK8MAPK10SMARCA2SMARCA4HDAC3 | |
| SCHEMBL24003891 | 0.78 | DNMT1 (0.51) | MAPK8MAPK10SMARCA2SMARCA4SORT1 | |
| SCHEMBL24006278 | 0.78 | DNMT1 (0.56) | MAPK8MAPK10SMARCA2SMARCA4SORT1 | |
| SCHEMBL24003987 | 0.75 | JAK2 (0.47) | MAPK8MAPK10SMARCA2SMARCA4HDAC3 | |
| SCHEMBL24003986 | 0.75 | MEN1 (0.46) | MAPK8MAPK10HDAC3HDAC1HDAC2 | |
| SCHEMBL23999774 | 0.73 | GRM4 (0.44) | HDAC3HDAC1HDAC2HDAC6SORT1 | |
| SCHEMBL23999808 | 0.71 | MAPT (0.45) | KMT2AALDH1A1GAA | |
| SCHEMBL30180568 | 0.71 | MAPT (0.45) | KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226517-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | MAPK8 134/4885MAPK10 60/4885SMARCA2 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.