Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 6/20 | 0.56 |
| ▸ | DNMT3A | Q9Y6K1 | 6/20 | 0.56 |
| ▸ | DNMT3L | Q9UJW3 | 4/20 | 0.51 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24003891 | 0.92 | DNMT1 (0.51) | DNMT1DNMT3ADNMT3LEHMT1BRAF | |
| SCHEMBL25461155 | 0.89 | DNMT1 (0.58) | DNMT1DNMT3ADNMT3LEHMT1BRAF | |
| SCHEMBL24006015 | 0.85 | DNMT1 (0.53) | DNMT1DNMT3ADNMT3LEHMT1BRAF | |
| SCHEMBL24003985 | 0.85 | JAK2 (0.44) | DNMT1DNMT3ADNMT3LEHMT1MEN1 | |
| SCHEMBL30287680 | 0.84 | NT5E (0.61) | DNMT1DNMT3ADNMT3LEHMT1BRAF | |
| SCHEMBL24006367 | 0.84 | NT5E (0.61) | DNMT1DNMT3ADNMT3LEHMT1BRAF | |
| SCHEMBL24003986 | 0.82 | MEN1 (0.46) | DNMT1DNMT3ADNMT3LBRAFMAPK8 | |
| SCHEMBL24010908 | 0.82 | BRAF (0.61) | BRAFNT5EMEN1KMT2A | |
| SCHEMBL30290852 | 0.82 | BRAF (0.61) | BRAFNT5EMEN1KMT2A | |
| SCHEMBL24010657 | 0.81 | BRAF (0.57) | DNMT1DNMT3ADNMT3LEHMT1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |