Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 8/20 | 0.54 |
| ▸ | DNMT3A | Q9Y6K1 | 7/20 | 0.54 |
| ▸ | DNMT3L | Q9UJW3 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30287679 | 1.00 | DNMT1 (0.54) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL24003828 | 1.00 | DNMT1 (0.54) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL30232520 | 1.00 | DNMT1 (0.54) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL26321794 | 0.89 | ABL1 (0.54) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL30290816 | 0.87 | DNMT1 (0.56) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL24010493 | 0.87 | DNMT1 (0.56) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL24006427 | 0.86 | BRAF (0.49) | DNMT1DNMT3ADNMT3LMAPTKMT2A | |
| SCHEMBL30290800 | 0.86 | BRAF (0.49) | DNMT1DNMT3ADNMT3LMAPTKMT2A | |
| SCHEMBL26309130 | 0.85 | DNMT1 (0.52) | DNMT1DNMT3ADNMT3LMAPTPOLB | |
| SCHEMBL24006101 | 0.83 | POLB (0.61) | DNMT1DNMT3ADNMT3LMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115867266-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |