Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.60 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.60 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011247 | 0.92 | DNMT1 (0.53) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL30290751 | 0.92 | DNMT1 (0.53) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL23999378 | 0.92 | MAPT (0.60) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL24003847 | 0.91 | DNMT1 (0.61) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL19151632 | 0.91 | DNMT1 (0.72) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL23999735 | 0.91 | DNMT1 (0.72) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL24006020 | 0.90 | MAPT (0.58) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL23999382 | 0.88 | MAPT (0.58) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL24003846 | 0.88 | MAPT (0.60) | MAPTUSP2KMT2ADNMT1DNMT3A | |
| SCHEMBL24006001 | 0.88 | MAPT (0.55) | MAPTUSP2KMT2ADNMT1DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |