Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 7/20 | 0.53 |
| ▸ | DNMT3A | Q9Y6K1 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | DNMT3L | Q9UJW3 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011247 | 1.00 | DNMT1 (0.53) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL25820658 | 0.94 | DNMT1 (0.55) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL24003841 | 0.93 | DNMT1 (0.53) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL24006237 | 0.92 | MAPT (0.60) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL24011037 | 0.91 | DNMT1 (0.52) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL30290879 | 0.91 | DNMT1 (0.52) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL30290771 | 0.91 | DNMT1 (0.61) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL24010920 | 0.91 | DNMT1 (0.61) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL30290960 | 0.91 | DNMT1 (0.62) | DNMT1DNMT3AKMT2AUSP2MAPT | |
| SCHEMBL24010213 | 0.91 | DNMT1 (0.62) | DNMT1DNMT3AKMT2AUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115996721-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-4146212-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |