Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 6/20 | 0.53 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30290913 | 0.94 | USP2 (0.49) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL24010928 | 0.94 | USP2 (0.49) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL24006007 | 0.90 | DNMT1 (0.52) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL25820663 | 0.88 | CDK8 (0.53) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL24006018 | 0.88 | DNMT1 (0.49) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL30290776 | 0.85 | DNMT1 (0.50) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL24010231 | 0.85 | DNMT1 (0.50) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL23999380 | 0.84 | USP2 (0.61) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL24006240 | 0.84 | USP2 (0.58) | DNMT1DNMT3AUSP2MAPTKMT2A | |
| SCHEMBL23999735 | 0.83 | DNMT1 (0.72) | DNMT1DNMT3AUSP2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |