Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.55 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010936 | 0.94 | USP2 (0.53) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL30290896 | 0.94 | USP2 (0.53) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL25849591 | 0.94 | USP2 (0.52) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL23999380 | 0.92 | USP2 (0.61) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL24006004 | 0.90 | USP2 (0.57) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL25820661 | 0.88 | DNMT1 (0.53) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL23999381 | 0.88 | USP2 (0.59) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL24006221 | 0.88 | KMT2A (0.57) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL24006016 | 0.88 | KMT2A (0.54) | USP2MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL23999735 | 0.87 | DNMT1 (0.72) | USP2MAPTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |