SCHEMBL24006299

SCHEMBL24006299

Cc1cc(Nc2ccc(NC(=O)c3cccc(Nc4ccnc5ccc(N6CCOCC6)cc45)c3)cc2)ccn1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 3/20 0.56
DNMT3A Q9Y6K1 3/20 0.56
MAPK10 P53779 2/20 0.52
EHMT1 Q9H9B1 2/20 0.51
DNMT3L Q9UJW3 2/20 0.51
SLC2A1 P11166 1/20 0.51
MAPKAPK2 P49137 2/20 0.50
MAPK14 Q16539 3/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
MAPT P10636 3/20 0.49
HTT P42858 1/20 0.49
RAB9A P51151 1/20 0.49
KDM4E B2RXH2 1/20 0.47
HPGD P15428 1/20 0.47
RAF1 P04049 2/20 0.47
BRAF P15056 2/20 0.47
EPHX2 P34913 1/20 0.47
TP53 P04637 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24005994 0.93 DNMT1 (0.59) DNMT1DNMT3AEHMT1DNMT3LMAPKAPK2
SCHEMBL24006305 0.92 MAPT (0.53) DNMT1DNMT3AMAPK10EHMT1DNMT3L
SCHEMBL24005997 0.92 MAPKAPK2 (0.47) DNMT1DNMT3AMAPK10EHMT1DNMT3L
SCHEMBL24006300 0.90 MAPK10 (0.52) MAPK10SLC2A1MAPKAPK2MAPK14SMN1; SMN2
SCHEMBL30180392 0.88 MAPT (0.54) MAPK10SLC2A1MAPKAPK2SMN1; SMN2MAPT
SCHEMBL23999785 0.88 MAPT (0.54) MAPK10SLC2A1MAPKAPK2SMN1; SMN2MAPT
SCHEMBL23999438 0.87 MAPT (0.49) MAPK10SLC2A1MAPKAPK2MAPK14SMN1; SMN2
SCHEMBL30180401 0.87 MAPT (0.49) MAPK10SLC2A1MAPKAPK2MAPK14SMN1; SMN2
SCHEMBL23999636 0.86 MAPT (0.53) DNMT1DNMT3AEHMT1DNMT3LMAPKAPK2
SCHEMBL30180473 0.86 MAPT (0.53) DNMT1DNMT3AEHMT1DNMT3LMAPKAPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2023081845-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2021226477-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2021-11-11 WO disclosed