Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.61 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.56 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.50 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30287680 | 1.00 | NT5E (0.61) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL30290950 | 0.95 | KCNK3 (0.61) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL30290838 | 0.95 | KCNK3 (0.61) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL24011296 | 0.95 | KCNK3 (0.61) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL24010261 | 0.95 | KCNK3 (0.61) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL24006303 | 0.91 | MAPK13 (0.61) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL24004056 | 0.90 | KCNK3 (0.57) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL30232732 | 0.90 | KCNK3 (0.57) | NT5EDNMT1DNMT3AKCNK3KCNK9 | |
| SCHEMBL23999629 | 0.90 | MAPT (0.63) | NT5EDNMT1DNMT3ALMNAJAK2 | |
| SCHEMBL23999624 | 0.90 | MAPT (0.63) | NT5EDNMT1DNMT3ALMNAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115867266-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |