Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.61 |
| ▸ | NT5E | P21589 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010375 | 0.93 | LMNA (0.53) | MAPK13NT5ELMNAHTTRAF1 | |
| SCHEMBL30290814 | 0.93 | LMNA (0.53) | MAPK13NT5ELMNAHTTRAF1 | |
| SCHEMBL24006367 | 0.91 | NT5E (0.61) | MAPK13NT5ELMNAHTTKMT2A | |
| SCHEMBL30287680 | 0.91 | NT5E (0.61) | MAPK13NT5ELMNAHTTKMT2A | |
| SCHEMBL24010361 | 0.90 | GRM5 (0.54) | MAPK13NT5ELMNAHTTKMT2A | |
| SCHEMBL23999626 | 0.90 | LMNA (0.55) | MAPK13LMNAKMT2ANPC1MEN1 | |
| SCHEMBL24006298 | 0.90 | MAPK13 (0.57) | MAPK13NT5ELMNAHTTRAF1 | |
| SCHEMBL24003736 | 0.87 | RAF1 (0.51) | MAPK13LMNAHTTRAF1KMT2A | |
| SCHEMBL30232529 | 0.87 | RAF1 (0.51) | MAPK13LMNAHTTRAF1KMT2A | |
| SCHEMBL24011296 | 0.86 | KCNK3 (0.61) | NT5ELMNAHTTKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |