Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PRCP | P42785 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010404 | 0.87 | P2RX7 (0.35) | PDE10AMEN1NPC1RAB9AKMT2A | |
| SCHEMBL30160504 | 0.87 | P2RX7 (0.35) | PDE10AMEN1NPC1RAB9AKMT2A | |
| SCHEMBL24010825 | 0.87 | P2RX7 (0.35) | PDE10AMEN1NPC1RAB9AKMT2A | |
| SCHEMBL24010865 | 0.87 | P2RX7 (0.35) | PDE10AMEN1NPC1RAB9AKMT2A | |
| SCHEMBL24010700 | 0.85 | PDE10A (0.37) | PDE10AEIF2AK4GSK3BPDE2ACYP1A2 | |
| SCHEMBL30160457 | 0.85 | PDE10A (0.37) | PDE10AEIF2AK4MEN1NPC1RAB9A | |
| SCHEMBL24009481 | 0.85 | PDE10A (0.37) | PDE10AEIF2AK4MEN1NPC1RAB9A | |
| SCHEMBL24001803 | 0.82 | GSK3B (0.37) | PDE10AEIF2AK4GSK3BPDE2ACYP1A2 | |
| SCHEMBL24002174 | 0.82 | GSK3B (0.37) | PDE10AEIF2AK4GSK3BPDE2ACYP1A2 | |
| SCHEMBL24002175 | 0.82 | GSK3B (0.37) | PDE10AEIF2AK4GSK3BPDE2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226629-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2021-11-11 | — | — | WO | disclosed |