Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 5/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010664 | 0.86 | PDE10A (0.35) | PDE10APDE2AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24836049 | 0.86 | PDE10A (0.37) | PDE10AEIF2AK4PDE2AGSK3BPIK3R2 | |
| SCHEMBL30160309 | 0.86 | PDE10A (0.35) | PDE10APDE2AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24009296 | 0.86 | PDE10A (0.35) | PDE10APDE2AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24010823 | 0.86 | PDE10A (0.35) | PDE10APDE2AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24009712 | 0.78 | PDE10A (0.38) | PDE10AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24010663 | 0.78 | PDE10A (0.38) | PDE10AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL30160660 | 0.78 | PDE10A (0.38) | PDE10AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24010661 | 0.78 | PDE10A (0.38) | PDE10AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL24009456 | 0.77 | PDE10A (0.36) | PDE10AEIF2AK4PDE2AGSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226629-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2021-11-11 | — | — | WO | disclosed |