Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 4/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 5/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30160660 | 0.84 | PDE10A (0.38) | SYKATRATRIP | |
| SCHEMBL24009712 | 0.84 | PDE10A (0.38) | SYKATRATRIP | |
| SCHEMBL24010663 | 0.84 | PDE10A (0.38) | SYKATRATRIP | |
| SCHEMBL24010661 | 0.84 | PDE10A (0.38) | SYKATRATRIP | |
| SCHEMBL24010664 | 0.76 | PDE10A (0.35) | LRRK2METGRM2 | |
| SCHEMBL24010823 | 0.76 | PDE10A (0.35) | LRRK2METGRM2 | |
| SCHEMBL30160309 | 0.76 | PDE10A (0.35) | LRRK2METGRM2 | |
| SCHEMBL24009296 | 0.76 | PDE10A (0.35) | LRRK2METGRM2 | |
| SCHEMBL24836049 | 0.76 | PDE10A (0.37) | SYKGRM2 | |
| SCHEMBL24009649 | 0.75 | PDE10A (0.38) | FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226629-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2021-11-11 | — | — | WO | disclosed |