Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | NSD2 | O96028 | 2/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30288433 | 1.00 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGNSD2 | |
| SCHEMBL5828984 | 0.87 | EPHA2 (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGNSD2 | |
| SCHEMBL664787 | 0.87 | EPHA2 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGNSD2 | |
| SCHEMBL17179600 | 0.87 | EPHA2 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGNSD2 | |
| SCHEMBL5827776 | 0.84 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGEPHA2 | |
| SCHEMBL3132645 | 0.83 | EPHA2 (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGNSD2 | |
| SCHEMBL1401725 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGEPHA2 | |
| SCHEMBL666523 | 0.81 | RAF1 (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGEPHA2 | |
| SCHEMBL4380906 | 0.81 | RAF1 (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGEPHA2 | |
| SCHEMBL1401690 | 0.81 | KDR (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGEPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| CN-115996912-A | Iminothiolanone inhibitors of ENPP1 | 沃拉斯查疗法公司 | 2023-04-21 | — | — | CN | disclosed |
| US-20230002406-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | US | disclosed |
| WO-2021225969-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | ENPP1, ENPP3, SMPD1 | PIK3CD 525/4885PIK3CA 430/4885PIK3CB 288/4885 |
| US-20230002406-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | ENPP1, ENPP3, SMPD1 | PIK3CD 525/4885PIK3CA 430/4885PIK3CB 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.