SCHEMBL24010802

SCHEMBL24010802

FC(F)(F)C1CC(Br)C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24097821 1.00
SCHEMBL13806340 0.84
SCHEMBL11762385 0.78 NOS3 (0.31)
SCHEMBL18057675 0.73
SCHEMBL13741650 0.72
SCHEMBL17892081 0.71 NOS3 (0.30)
SCHEMBL30951928 0.69
SCHEMBL30951925 0.69
SCHEMBL18057680 0.68
SCHEMBL14225386 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260049080-A1 WILD TYPE KIT INHIBITORS BLUEPRINT MEDICINES CORP (US) 2026-02-19 US disclosed
EP-4653050-A2 CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS Amgen Inc. (US) 2025-11-26 EP disclosed
EP-4637749-A2 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2025-10-29 EP disclosed
US-12448379-B2 Wild type kit inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2025-10-21 US disclosed
US-12428425-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use AMGEN INC. (US) 2025-09-30 US disclosed
EP-4165024-B1 CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS AMGEN INC (US) 2025-07-16 EP disclosed
US-20250171425-A1 USES OF CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS AMGEN INC. 2025-05-29 US disclosed
CN-119735588-A Cyclobutyl dihydroquinolines sulfonamide compounds 美国安进公司 2025-04-01 CN disclosed
US-20250099448-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2025-03-27 US disclosed
US-12240839-B2 Cyclobutyl dihydroquinoline sulfonamide compounds AMGEN INC. (US) 2025-03-04 US disclosed
US-11608344-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use AMGEN INC. (US) 2023-03-21 US disclosed
WO-2023023202-A1 STEREOSELECTIVE PREPARATION OF TRANS HALO CYCLOBUTANE AMGEN INC. (US) 2023-02-23 WO disclosed
CN-115697971-A Cyclobutyldihydroquinoline sulfonamide compound 美国安进公司 2023-02-03 CN disclosed
US-20230002390-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE AMGEN INC. 2023-01-05 US disclosed
WO-2022236272-A2 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. (US) 2022-11-10 WO disclosed
US-20220306604-A1 CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS AMGEN INC. (US) 2022-09-29 US disclosed
US-20220098176-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2022-03-31 US disclosed
US-20210387978-A1 CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS AMGEN INC. (US) 2021-12-16 US disclosed
WO-2021252820-A1 CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS AMGEN INC. (US) 2021-12-16 WO disclosed
WO-2021226629-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE AMGEN INC. (US) 2021-11-11 WO disclosed