Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26763681 | 0.84 | LMNA (0.46) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL8499984 | 0.80 | ACACB (0.51) | ACACB | |
| SCHEMBL12412599 | 0.76 | LMNA (0.50) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL29438094 | 0.76 | LMNA (0.53) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL13282056 | 0.75 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL22766246 | 0.74 | CYP19A1 (0.50) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL2421346 | 0.74 | CYP19A1 (0.50) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL28187837 | 0.74 | CYP3A4 (0.51) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL24016011 | 0.74 | LMNA (0.48) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL26464570 | 0.74 | LMNA (0.48) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |