Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19161264 | 0.91 | HDAC6 (0.84) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19138891 | 0.91 | HDAC6 (0.84) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL17500213 | 0.88 | HDAC6 (1.00) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19162246 | 0.88 | HDAC6 (1.00) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19162236 | 0.87 | HDAC6 (0.78) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19139000 | 0.87 | HDAC6 (0.78) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19168902 | 0.81 | HDAC6 (0.86) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19138920 | 0.80 | HDAC6 (0.84) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19167613 | 0.80 | HDAC6 (0.67) | HDAC6HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL19162239 | 0.79 | HDAC6 (0.83) | HDAC6HDAC4HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |