Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.77 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19138981 | 0.89 | HDAC6 (0.83) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL18070822 | 0.87 | ENPP2 (0.84) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL17520522 | 0.87 | HDAC6 (1.00) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL19138923 | 0.87 | HDAC6 (1.00) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL14104796 | 0.86 | HDAC6 (0.70) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL24011800 | 0.86 | HDAC6 (0.75) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL19161139 | 0.86 | HDAC6 (0.77) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL19139010 | 0.84 | HDAC6 (0.82) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL24011865 | 0.82 | HDAC6 (0.75) | HDAC6ENPP2HDAC4HDAC1HDAC2 | |
| SCHEMBL17520628 | 0.81 | HDAC6 (1.00) | HDAC6ENPP2HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |