Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28221148 | 0.83 | HPGD (0.69) | HPGDKDM4EHTTPOLBKMT2A | |
| SCHEMBL19747178 | 0.83 | HPGD (0.69) | HPGDKDM4EHTTPOLBKMT2A | |
| SCHEMBL22720161 | 0.83 | HPGD (0.69) | HPGDKDM4EHTTPOLBKMT2A | |
| SCHEMBL2234130 | 0.82 | HPGD (1.00) | HPGDHTTPOLBKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL28152221 | 0.81 | HPGD (0.97) | HPGDHTTPOLBKMT2ALMNA | |
| SCHEMBL4521778 | 0.80 | GAA (0.64) | HPGDKDM4EHTTPOLBKMT2A | |
| SCHEMBL11482378 | 0.78 | KDM4C (0.68) | HPGDKDM4EPOLBKMT2ALMNA | |
| SCHEMBL3561734 | 0.78 | POLB (0.70) | HPGDKDM4EHTTPOLBKMT2A | |
| SCHEMBL10889755 | 0.77 | KMT2A (0.69) | KDM4EHTTKMT2AAPEX1LMNA | |
| SCHEMBL14484111 | 0.77 | HPGD (0.82) | HPGDHTTPOLBKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017628-B2 | Pharmaceutically active sulfonyl hydrazide derivatives | MERCK SERONO S.A. (CH) | 2011-09-13 | — | — | US | disclosed |
| US-20090005426-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-01-01 | — | — | US | disclosed |
| US-7432286-B1 | Pharmaceutically active sulfonyl hydrazide derivatives | LABORATORIES SERONO SA (CH) | 2008-10-07 | — | — | US | disclosed |
| EP-1216245-B1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2004-05-26 | — | — | EP | disclosed |
| EP-1216245-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023382-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-05 | — | — | WO | disclosed |
| EP-1088822-A1 | Pharmaceutically active sulfonyl hydrazide derivatives | Applied Research Systems ARS Holding N.V. (AN) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005426-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | SLC5A1, SLC5A2, IAPP | HPGD 558/4885KDM4E 3183/4885HTT 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.