Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.63 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.63 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.63 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24016143 | 0.92 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PPARG | |
| SCHEMBL24016560 | 0.91 | TEAD1 (0.59) | TEAD1TEAD4TEAD2TEAD3PPARG | |
| SCHEMBL24015985 | 0.89 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3PIK3CA | |
| SCHEMBL24015678 | 0.89 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PPARG | |
| SCHEMBL24016247 | 0.89 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PPARG | |
| SCHEMBL25042805 | 0.88 | TEAD1 (0.47) | TEAD1TEAD4TEAD2TEAD3PIK3CA | |
| SCHEMBL24015634 | 0.87 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3PIK3CA | |
| SCHEMBL24016185 | 0.87 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PIK3CA | |
| SCHEMBL24016492 | 0.86 | TEAD1 (0.67) | TEAD1TEAD4TEAD2TEAD3PPARG | |
| SCHEMBL24016493 | 0.86 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |