Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.63 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.63 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.63 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24016493 | 0.91 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24015634 | 0.91 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016637 | 0.87 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016104 | 0.87 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016492 | 0.86 | TEAD1 (0.67) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016248 | 0.86 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL30561352 | 0.85 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL25381780 | 0.85 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL24016565 | 0.85 | MEN1 (0.55) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016228 | 0.85 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |