Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.61 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.61 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.61 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055697 | 0.86 | TEAD1 (0.62) | TEAD1TEAD4TEAD2TEAD3CHRNA7 | |
| SCHEMBL24015955 | 0.86 | TEAD1 (0.62) | TEAD1TEAD4TEAD2TEAD3CHRNA7 | |
| SCHEMBL24015891 | 0.85 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3CHRNA7 | |
| SCHEMBL24016542 | 0.84 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3TRPV1 | |
| SCHEMBL24016057 | 0.81 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015634 | 0.79 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015629 | 0.79 | TEAD1 (0.65) | TEAD1TEAD4TEAD2TEAD3TRPV1 | |
| SCHEMBL30056900 | 0.79 | TEAD1 (0.65) | TEAD1TEAD4TEAD2TEAD3TRPV1 | |
| SCHEMBL24016173 | 0.79 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3CHRNA7 | |
| SCHEMBL24016129 | 0.77 | TEAD1 (0.74) | TEAD1TEAD4TEAD2TEAD3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |