Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.62 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.62 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.62 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015955 | 1.00 | TEAD1 (0.62) | TEAD1TEAD4TEAD2TEAD3POLB | |
| SCHEMBL24015891 | 0.86 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3POLB | |
| SCHEMBL24016502 | 0.86 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3POLB | |
| SCHEMBL24015646 | 0.85 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3POLB | |
| SCHEMBL30055916 | 0.85 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3POLB | |
| SCHEMBL24016057 | 0.82 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3POLB | |
| SCHEMBL24015634 | 0.80 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015629 | 0.80 | TEAD1 (0.65) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL30056900 | 0.80 | TEAD1 (0.65) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24016563 | 0.79 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334319-A1 | 2,8-DIHYDROPYRAZOLO[3,4-B]INDOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Merck Patent GmbH (DE) | 2024-03-13 | — | — | EP | disclosed |
| CN-117616028-A | 2, 8-dihydropyrazolo [3,4-B ] indole derivatives for the treatment of cancer | 默克专利股份公司 | 2024-02-27 | — | — | CN | disclosed |
| EP-4146652-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | Merck Patent GmbH (DE) | 2023-03-15 | — | — | EP | disclosed |
| CN-115515959-A | Tricyclic heterocycles as TEAD binders | 默克专利股份公司 | 2022-12-23 | — | — | CN | disclosed |
| WO-2022233442-A1 | 2,8-DIHYDROPYRAZOLO[3,4-B]INDOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2022-11-10 | — | — | WO | disclosed |