SCHEMBL24016972

SCHEMBL24016972

CC(c1cncc(N)n1)C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 1/20 0.38
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
KCNH2 Q12809 2/20 0.31
SCN5A Q14524 2/20 0.31
SCN9A Q15858 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30354636 0.77 NOS3 (0.48) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL2760432 0.77 NOS3 (0.48) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL20692815 0.77 CDK2 (0.42) CDK2KCNH2SCN5ASCN9A
SCHEMBL31226557 0.75 CDK2 (0.43) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL31226663 0.75 CDK2 (0.43) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL31226309 0.75 CDK2 (0.43) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL4422443 0.75 CDK2 (0.43) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL15664878 0.73 CDK2 (0.44) CDK2NOS3NOS1NOS2KCNH2
SCHEMBL22426961 0.71 CDK2 (0.39) CDK2NOS3NOS1NOS2
SCHEMBL24796831 0.69 CDK2 (0.38) CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3645484-B1 METHOD FOR PREPARATION OF ALKYLATED OR FLUORO, CHLORO AND FLUOROCHLORO ALKYLATED COMPOUNDS BY HETEROGENEOUS COBALT CATALYSIS LONZA SOLUTIONS AG (CH) 2021-11-10 EP disclosed