Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402243 | 1.00 | CCR8 (0.52) | CCR8L3MBTL1ALDH1A1TSHRMEN1 | |
| SCHEMBL2402658 | 0.98 | CCR8 (0.52) | CCR8L3MBTL1ALDH1A1TSHRMEN1 | |
| SCHEMBL2402655 | 0.98 | CCR8 (0.52) | CCR8L3MBTL1ALDH1A1TSHRMEN1 | |
| SCHEMBL2405887 | 0.85 | CCR8 (0.53) | CCR8ALDH1A1TSHREPHX2HSD11B1 | |
| SCHEMBL2405883 | 0.85 | CCR8 (0.53) | CCR8ALDH1A1TSHREPHX2HSD11B1 | |
| SCHEMBL2401720 | 0.84 | CCR8 (0.52) | CCR8ALDH1A1TSHRHSD11B1HRH3 | |
| SCHEMBL2401724 | 0.84 | CCR8 (0.52) | CCR8ALDH1A1TSHRHSD11B1HRH3 | |
| SCHEMBL2401777 | 0.82 | ATM (0.56) | CCR8L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2401780 | 0.82 | ATM (0.56) | CCR8L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2402205 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017773-B2 | Cyclohexyl sulfonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-09-13 | — | — | US | claimed |
| CN-101370779-B | Cyclohexyl sulfonamide derivatives having H3 receptor activity | HOFFMANN LA ROCHE | 2011-07-20 | — | — | CN | claimed |
| EP-1979322-B1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES HAVING H3 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2010-09-01 | — | — | EP | claimed |
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | claimed |
| CN-101370779-A | Cyclohexyl sulfonamide derivatives having H3 receptor activity | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | CN | claimed |
| EP-1979322-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES HAVING H3 RECEPTOR ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082840-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES HAVING H3 RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | US | claimed |
| US-8017773-B2 | Cyclohexyl sulfonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-09-13 | — | — | US | disclosed |
| CN-101370779-B | Cyclohexyl sulfonamide derivatives having H3 receptor activity | HOFFMANN LA ROCHE | 2011-07-20 | — | — | CN | disclosed |
| EP-1979322-B1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES HAVING H3 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2010-09-01 | — | — | EP | disclosed |
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | disclosed |
| CN-101370779-A | Cyclohexyl sulfonamide derivatives having H3 receptor activity | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | CN | disclosed |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | HRH3, HRH4, HRH1 | CCR8 1481/4885L3MBTL1 3656/4885ALDH1A1 430/4885 |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | HRH3, HRH4, HRH1 | CCR8 1481/4885L3MBTL1 3656/4885ALDH1A1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.